ABSTRACT
For induction of humoral or cell-mediated immunity, development of synthetic peptide vaccines present a novel approach and a better alternative to conventional vaccines. Construction of synthetic peptides that mimic antigenic sites is the basis of this approach. In this article various methodologies involved in the peptide synthesis are discussed. This is followed by a discussion on the strategies involved in rendering poor or non-immunogenic peptides immunogenic. These include coupling to large carrier proteins, polymeric presentation and incorporation of an identified Th cell epitope into the peptide.
Subject(s)
Animals , B-Lymphocytes/immunology , Epitopes/immunology , Histocompatibility Antigens , Humans , Methods , Peptides/chemical synthesis , T-Lymphocytes/immunology , Vaccination/trends , Vaccines, Synthetic/immunologyABSTRACT
There has been tremendous progress in leprosy control globally and in Oman. In Oman, leprosy has been eliminated and recently the control programme has been reactivated to aim at total eradication. This article outlines the prevailing leprosy situation in Oman
Subject(s)
Humans , Leprosy, Lepromatous , Leprosy, Tuberculoid , Leprosy, Borderline , Leprostatic Agents , Leprosy/prevention & controlABSTRACT
Sexually transmitted diseases [STDs] are important public health problems. Recently WHO has recommended the syndromic approach for management of these diseases and the same has been adapted in the national STD control programme of Ministry of Health in Oman. This paper explains the advantages of syndromic approach and how it is integrated with preventive measures such as partner management, counselling and provision of condoms